pentobarbital will lessen the level or effect of ritonavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will lower the extent or outcome of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.pentobarbital will decrease the extent or influence of rolapitant… Read More